Review article · Vol 1, No 2 · January–April 2013 · pp. 43-50
Genetic Basis of Non Syndromic Cleft Lip and Palate
Shweta Dixit Chaudhary1, Mayur Chaudhary2, Sanket Kunte3, Mahesh Gabhane4, Suyog Tupsakhare4
- 1 Associate Professor, Dept. of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra
- 2 Associate Professor, Dept. of Oral Pathology and Microbiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra
- 3 Senior Lecturer, Dept. of Pedodontics and Preventive Dentistry, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra
- 4 Senior Lecturer, Dept. of Oral Pathology and Microbiology, SMBT Dental College and Hospital, Sangamner, Ahmednagar, India
Abstract
There are many processes which could play a role in the formation of the lip and palate, and each of these requires different key molecules to be made normally. Genetic mutations could alter the function of any of these molecules, which could lead to cleft lip or palate. Heredity, probably a dominant gene with limited penetrance, is thought to be the main etiologic cause. Another theory is a combination of inheritance and multiple other factors. Factors implicated in the etiology of cleft lip and palate and cleft palate only include the gene (TGFA) encoding transforming growth factor-α (TGFα), transforming growth factors (TGFα and TGFβ isoforms), particularly TGFα, TGFβ1 and TGFβ3 isoform expressions and their effects on ECM macromolecule production, B-cell leukemia/lymphoma 3 (BCL3), retinoic acid receptor α (RARα), linkage with F13A (blood clotting factor XIIIA) on chromosome 6, locus in the region 4q25–4q31.3 on chromosome 4 and various environmental factors.
Keywords Cleft lip and palateGeneticTransforming growth factorRetinoic acid receptor
How to cite
Chaudhary SD, Chaudhary M, Kunte S, Gabhane M, Tupsakhare S. Genetic Basis of Non Syndromic Cleft Lip and Palate. Int J Dent Pract Med Sci. 2013;1(2):43-50.
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